P-gp preferentially transports relatively large, lipophilic and positively charged molecules[13]
P-gp preferentially transports relatively large, lipophilic and positively charged molecules[13]. field, the present review will focus on cellular mechanisms of drug resistance in colon cancer and its reversal strategies, with an emphasis on the over-expression of drug efflux LDC1267 transporters and evasion of apoptosis, two associates of transport-based and non-transport-based cellular mechanisms, respectively. TRANSPORT-BASED CELLULAR […]