[PubMed] [Google Scholar] 34
[PubMed] [Google Scholar] 34. apoptosis. Pellino-1 overexpression in A549 and H1299 cells upregulated the manifestation of inhibitor of apoptosis (IAP) protein, including cIAP2 Eflornithine hydrochloride hydrate and cIAP1, while Pellino-1 depletion downregulated these substances. Notably, Pellino-1 straight interacted with cIAP2 and stabilized cIAP2 through lysine63-mediated polyubiquitination via its E3 ligase activity. Pellino-1-mediated chemoresistance in lung […]