Lastly, we found that low doses of estradiol (0
Lastly, we found that low doses of estradiol (0.01 M) significantly potentiated the ability of progesterone to inhibit expression of sFRP4 transcript in leiomyomas [Fig. in a dose-dependent manner sensitized by estradiol. Knockdown of sFRP4 inhibited proliferation and apoptosis in primary cultures of both myometrium and leiomyoma. Conclusions: Overexpression of sFRP4 is usually a strong, […]